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KMID : 0358319960370101093
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Korean Journal of Urology
1996 Volume.37 No. 10 p.1093 ~ p.1096
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The Relationship of Cellular Composition of Benign Prostatic Hyperplasia and Prostate-Specific Antigen(PSA) Levels
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Abstract
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The relationship between the serum values of prostate-specific antigen (PSA) and the histologic composition of benign prostatic hyperplasia (BPH0 was investigated in 32 symptomatic BPH patients undergoing transurethral resection of the prostate.
We
evaluated the free and total PSA concentrations by ACS-PSA2 (Ciba-Corning) assay. The stereological analysis was made by computer aided-arca densitometry using H & E stained slides to quantify stromal and glandular areas inh the resected prostate
tissue.
The total PSA concentration versus precentage of glandular area (%G) and stromal-glandular ratio (SGR0 correlated significantly (p<0.05 for both) whereas the PSA concentration and free/total PSA ratio did not (p>0.05 for both).
These data suggest that total PAS is directly correlated with the histologic composition of the prostate in men with BPH, however, the proportion of free to total PAS was not informative to predict the histology. Thus, pretreatment evaulation of
total
PSA would be useful as part of an evaluation method of BPH for medical therapy.
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